A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults
Journal article, 2018
© 2018, The Author(s). Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres.
Author
Lea B.S. Hansen
Technical University of Denmark (DTU)
Henrik M. Roager
Technical University of Denmark (DTU)
University of Copenhagen
Nadja B. Søndertoft
University of Copenhagen
Rikke J. Gøbel
University of Copenhagen
M. Kristensen
University of Copenhagen
Mireia Vallès-Colomer
KU Leuven
Flanders Interuniversity Institute for Biotechnology
Sara Vieira-Silva
Flanders Interuniversity Institute for Biotechnology
KU Leuven
Sabine Ibrügger
University of Copenhagen
Mads Vendelbo Lind
University of Copenhagen
Rasmus B. Mærkedahl
University of Copenhagen
Martin I. Bahl
Technical University of Denmark (DTU)
M. L. Madsen
University of Copenhagen
Jesper Havelund
University of Southern Denmark
Gwen Falony
KU Leuven
Flanders Interuniversity Institute for Biotechnology
Inge Tetens
University of Copenhagen
Trine Nielsen
University of Copenhagen
Kristine H. Allin
University of Copenhagen
Henrik L. Frandsen
Technical University of Denmark (DTU)
Bolette Hartmann
University of Copenhagen
Jens Juul Holst
University of Copenhagen
Morten H. Sparholt
Bispebjerg Hospital
Jesper Holck
Technical University of Denmark (DTU)
Andreas Blennow
University of Copenhagen
Janne Marie Moll
Technical University of Denmark (DTU)
Anne S. Meyer
Technical University of Denmark (DTU)
Camilla Hoppe
Technical University of Denmark (DTU)
Jørgen H. Poulsen
Hvidovre Hospital
Vera Carvalho
Technical University of Denmark (DTU)
Domenico Sagnelli
University of Copenhagen
Marlene D. Dalgaard
Technical University of Denmark (DTU)
Anders F. Christensen
Bispebjerg Hospital
Magnus Christian Lydolph
Statens Serum Institut
Alastair Ross
Chalmers, Biology and Biological Engineering, Food and Nutrition Science
S.G.R. Villas-Bôas
University of Auckland
Susanne Brix
Technical University of Denmark (DTU)
T. Sicheritz-Pontén
Technical University of Denmark (DTU)
Karsten Buschard
Rigshospitalet
Allan Linneberg
Research Centre for Prevention and Health
Jüri J. Rumessen
Amtssygehuset i Gentofte
Claus T. Ekstrøm
University of Copenhagen
Christian Ritz
University of Copenhagen
Karsten Kristiansen
University of Copenhagen
H. Bjørn Nielsen
Clinical-Microbiomics A/S
H. Vestergaard
University of Copenhagen
Nils J. Færgeman
University of Southern Denmark
Jeroen Raes
Flanders Interuniversity Institute for Biotechnology
KU Leuven
Hanne Frøkiær
University of Copenhagen
Torben Hansen
University of Copenhagen
L. Lauritzen
University of Copenhagen
Ramneek Gupta
Technical University of Denmark (DTU)
Tine Rask Licht
Technical University of Denmark (DTU)
O. B. Pedersen
University of Copenhagen
Nature Communications
2041-1723 (ISSN) 20411723 (eISSN)
Vol. 9 1 4630Subject Categories
Food Science
Clinical Science
Nutrition and Dietetics
DOI
10.1038/s41467-018-07019-x
PubMed
30425247