Biodegradation of graphene materials catalyzed by human eosinophil peroxidase
Journal article, 2021

Understanding the biodegradability of graphene materials by the action of oxidative enzymes secreted by immune cells is essential for developing applicable biomedical products based on these materials. Herein, we demonstrate the biodegradation of graphene oxide (GO) by recombinant eosinophil peroxidase (EPO) enzyme extracted from human eosinophils in the presence of a low concentration of hydrogen peroxide and NaBr. We compared the degradation capability of the enzyme on three different GO samples containing different degrees of oxygen functional groups on their graphenic lattices. EPO succeeded in degrading the three tested GO samples within 90 h treatment. Raman spectroscopy and transmission electron microscopy analyses provided clear-cut evidence for the biodegradation of GO by EPO catalysis. Our results provide more insight into a better understanding of the biodegradation of graphene materials, helping the design of future biomedical products based on these carbon nanomaterials.


Rajendra Kurapati

University of Strasbourg

Cristina Martin

University of Strasbourg

Vincenzo Palermo

Chalmers, Industrial and Materials Science, Materials and manufacture

National Research Council of Italy (CNR)

Yuta Nishina

Okayama University

Alberto Bianco

University of Strasbourg

Faraday Discussions

1359-6640 (ISSN) 1364-5498 (eISSN)

Vol. 227 0 189-203

Subject Categories

Polymer Technologies

Materials Chemistry

Other Chemistry Topics





More information

Latest update