Viral blips during suppressive antiretroviral treatment are associated with high baseline HIV-1 RNA levels
Journal article, 2016

Background: Many HIV-1-infected patients on suppressive antiretroviral therapy (ART) have transiently elevated HIV RNA levels. The clinical significance of these viral blips is uncertain. We have determined the incidence of blips and investigated important associations in the Swedish HIV-cohort. Methods: HIV-1-infected ART naiive adults who commenced ART 2007-2013 were retrospectively included. Viral blips were defined as a transient viral load between 50 and 500 copies/mL Subjects not suppressed after six months on ART were excluded. Results: Viral blips were found in 76/735 included subjects (10.3%) and in 90/4449 samples (2.0%). Median blip viral load was 76 copies/mL (range 56-138). Median follow-up time was 170weeks (range 97-240). Baseline viral load was higher in subjects with viral blips (median log 10 4.85 copies/mL) compared with subjects without blips (median log 10 4.55 copies/mL) (p < 0.01). There was a significant association between viral blips and risk for subsequent virological failure (p < 0.001). Conclusions: The Swedish national HIV-cohort has a low incidence of viral blips (10%). Blips were associated with high baseline viral load and an increased risk of subsequent virological failure.

Author

Erik Sörstedt

University of Gothenburg

Staffan Nilsson

Chalmers, Mathematical Sciences, Applied Mathematics and Statistics

A. Blaxhult

Magnus Gisslén

University of Gothenburg

Leo Flamholc

Skåne University Hospital

A Sönnerborg

Karolinska University Hospital

Aylin Yilmaz

University of Gothenburg

BMC Infectious Diseases

1471-2334 (ISSN)

Vol. 16 1 305

Subject Categories

Infectious Medicine

Gastroenterology and Hepatology

Cardiac and Cardiovascular Systems

DOI

10.1186/s12879-016-1628-6

More information

Latest update

2/13/2019