Health‐related Research Ethics and Social Value: Antibiotic Resistance Intervention Research and Pragmatic Risks
Journal article, 2019

We consider the implications for the ethical evaluation of research programs of two fundamental changes in the revised research ethical guideline of the Council for International Organizations of Medical Sciences. The first is the extension of scope that follows from exchanging “biomedical” for “health‐related”research, and the second is the new evaluative basis of “ocial value,”which implies new ethical requirements of research. We use the example of antibiotic resistance interventions to explore the need to consider what we term the pragmatic risks of such interventions to evaluate the social value of certain kinds of health‐related research. These (pragmatic) risks severely threaten the social value of interventions in every area where human and social responses significantly impact on their effectiveness. Thus, the social value of health‐related research needed to demonstrate its effectiveness depends on the successful management of such risks. Research designed to take into account pragmatic risks also gives rise to similar types of risks, and the potential for social value in light of those risks needs to be considered in ethical reviews based on the new guidelines. We argue that, to handle this new expanded task, the international system of research ethical review addressed by the guidelines needs institutional development. In particular, we consider lifting research ethical review to a level closer to actual health policy making.

drug resistance

antimicrobial resistance

CIOMS

evidence‐based practice

health policy

Author

Christian Munthe

University of Gothenburg

Karl de Fine Licht

Chalmers, Technology Management and Economics, Science, Technology and Society

Niels Nijsingh

University of Gothenburg

Joakim Larsson

University of Gothenburg

Bioethics

0269-9702 (ISSN) 1467-8519 (eISSN)

Vol. 33 3 335-342

Subject Categories

Ethics

Philosophy

Social Sciences Interdisciplinary

Driving Forces

Sustainable development

DOI

10.1111/bioe.12580

PubMed

30884548

More information

Latest update

10/7/2019