Water transport and absorption in pharmaceutical tablets – a numerical study
Journal article, 2019

The quality of a coated pharmaceutical tablet can be strongly affected by the interactions of water droplets with the porous substrate during processes such as coating process. Three different mechanisms co-exist in the coating process: water spreading, absorption and evaporation. Disentangling the fundamental understanding of these phenomena can therefore be crucial for achieving a higher quality of the products (e.g. a longer shelf-life of the tablets) and for controlling the efficiency of the process. This paper aims to investigate the spreading and absorption mechanisms after droplet impingement on a tablet using a Lattice-Boltzmann methodology. Our numerical results (droplet height and spreading, penetration depth and absorbed volume) are in a good agreement with experimental data and numerical simulations available in the literature. In particular, the spreading phase is characterised by the capillary spreading time scale, as confirmed by previous studies. In contrast to previous studies, we find that the absorption process begins at times shorter than the capillary spreading time but with a different power-law in the absorbed volume. We explain this behaviour through a modified Washburn law that takes into account three-dimensional effects. Our data can be used as a benchmark to test novel mathematical models.

Porous tablets

Pharmaceutical coating

Absorption

Droplet impact

Mathematical modelling

Author

Povilas Vaitukaitis

Chalmers, Mechanics and Maritime Sciences, Fluid Dynamics

Dario Maggiolo

Chalmers, Mechanics and Maritime Sciences, Fluid Dynamics

Johan Remmelgas

AstraZeneca R&D

Susanna Abrahmsén-Alami

AstraZeneca R&D

Diana Bernin

Chalmers, Chemistry and Chemical Engineering, Chemical Technology, Chemical Engineering Design

Maria Daniela Irene Siiskonen

Chalmers, Industrial and Materials Science, Product Development

Johan Malmqvist

Chalmers, Industrial and Materials Science, Product Development

Srdjan Sasic

Chalmers, Mechanics and Maritime Sciences, Fluid Dynamics

Gaetano Sardina

Chalmers, Mechanics and Maritime Sciences, Fluid Dynamics

Meccanica

0025-6455 (ISSN) 1572-9648 (eISSN)

Vol. 55 2 421-433

Subject Categories

Pharmaceutical Chemistry

Chemical Process Engineering

Fluid Mechanics and Acoustics

Driving Forces

Sustainable development

Areas of Advance

Production

Infrastructure

C3SE (Chalmers Centre for Computational Science and Engineering)

DOI

10.1007/s11012-019-01103-2

More information

Latest update

3/10/2020