Development of fungal cell factories for the production of secondary metabolites: Linking genomics and metabolism
Artikel i vetenskaplig tidskrift, 2017

The genomic era has revolutionized research on secondary metabolites and bioinformatics methods have in recent years revived the antibiotic discovery process after decades with only few new active molecules being identified. New computational tools are driven by genomics and metabolomics analysis, and enables rapid identification of novel secondary metabolites. To translate this increased discovery rate into industrial exploitation, it is necessary to integrate secondary metabolite pathways in the metabolic engineering process. In this review, we will describe the novel advances in discovery of secondary metabolites produced by filamentous fungi, highlight the utilization of genome-scale metabolic models (GEMs) in the design of fungal cell factories for the production of secondary metabolites and review strategies for optimizing secondary metabolite production through the construction of high yielding platform cell factories.

Secondary metabolism

Fungi

Genome mining

Biosynthetic gene clusters

metabolic modeling

cell factories

Författare

Jens Christian Froslev Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

Synthetic and Systems Biotechnology

2405-805X (eISSN)

Vol. 2 1 5-12

Fundament

Grundläggande vetenskaper

Drivkrafter

Innovation och entreprenörskap

Styrkeområden

Livsvetenskaper och teknik

Ämneskategorier

Bioinformatik och systembiologi

DOI

10.1016/j.synbio.2017.02.002

Mer information

Senast uppdaterat

2018-05-29