Viral blips during suppressive antiretroviral treatment are associated with high baseline HIV-1 RNA levels
Artikel i vetenskaplig tidskrift, 2016

Background: Many HIV-1-infected patients on suppressive antiretroviral therapy (ART) have transiently elevated HIV RNA levels. The clinical significance of these viral blips is uncertain. We have determined the incidence of blips and investigated important associations in the Swedish HIV-cohort. Methods: HIV-1-infected ART naiive adults who commenced ART 2007-2013 were retrospectively included. Viral blips were defined as a transient viral load between 50 and 500 copies/mL Subjects not suppressed after six months on ART were excluded. Results: Viral blips were found in 76/735 included subjects (10.3%) and in 90/4449 samples (2.0%). Median blip viral load was 76 copies/mL (range 56-138). Median follow-up time was 170weeks (range 97-240). Baseline viral load was higher in subjects with viral blips (median log 10 4.85 copies/mL) compared with subjects without blips (median log 10 4.55 copies/mL) (p < 0.01). There was a significant association between viral blips and risk for subsequent virological failure (p < 0.001). Conclusions: The Swedish national HIV-cohort has a low incidence of viral blips (10%). Blips were associated with high baseline viral load and an increased risk of subsequent virological failure.

Författare

Erik Sörstedt

Göteborgs universitet

Staffan Nilsson

Chalmers, Matematiska vetenskaper, Tillämpad matematik och statistik

A. Blaxhult

Organisation okänd

Magnus Gisslén

Göteborgs universitet

Leo Flamholc

Skånes universitetssjukhus (SUS)

A Sönnerborg

Karolinska universitetssjukhuset

Aylin Yilmaz

Göteborgs universitet

BMC Infectious Diseases

1471-2334 (ISSN)

Vol. 16 1 305

Ämneskategorier

Infektionsmedicin

Gastroenterologi

Kardiologi

DOI

10.1186/s12879-016-1628-6

Mer information

Senast uppdaterat

2018-05-14