mRNA function after intracellular delivery and release
Artikel i vetenskaplig tidskrift, 2018

Nanocarrier-mediated mRNA delivery and release into the cells with subsequent translation to protein is of interest in the context of the development of a new generation of drugs. In particular, this protein can play a role of a transcription factor and be used as a tool to regulate temporarily the genetic networks. The corresponding transient kinetics of gene expression are expected to depend on the mechanism and duration of mRNA release. Assuming the release to be rapid on the time scale of other steps, the author shows theoretically the mRNA-related transient features of gene expression occurring in stable, bistable, and oscillatory regimes in a single cell. Qualitatively, the results obtained are found to be fairly similar to those reported earlier for the situation when the release is slow. Thus, the features of the transient kinetics under consideration appear to be less sensitive to the duration of mRNA release compared to what one might expect.

Mean-field kinetic equations

Subcellular processes

Gene expression

Drug delivery

Författare

Vladimir Zhdanov

Russian Academy of Sciences

Chalmers, Fysik, Kemisk fysik

BioSystems

0303-2647 (ISSN)

Vol. 165 52-56

Ämneskategorier

Cellbiologi

Cell- och molekylärbiologi

Bioinformatik och systembiologi

DOI

10.1016/j.biosystems.2018.01.003

PubMed

29331630