Transformation of amorphous calcium phosphate to bone-like apatite
Artikel i vetenskaplig tidskrift, 2018

Mineralisation of calcium phosphates in bone has been proposed to proceed via an initial amorphous precursor phase which transforms into nanocrystalline, carbonated hydroxyapatite. While calcium phosphates have been under intense investigation, the exact steps during the crystallisation of spherical amorphous particles to platelet-like bone apatite are unclear. Herein, we demonstrate a detailed transformation mechanism of amorphous calcium phosphate spherical particles to apatite platelet-like crystals, within the confined nanodomains of a bone-inspired nanocomposite. The transformation is initiated under the presence of humidity, where nanocrystalline areas are formed and crystallisation advances via migration of nanometre sized clusters by forming steps at the growth front. We propose that such transformation is a possible crystallisation mechanism and is characteristic of calcium phosphates from a thermodynamic perspective and might be unrelated to the environment. Our observations provide insight into a crucial but unclear stage in bone mineralisation, the origins of the nanostructured, platelet-like bone apatite crystals.

Författare

Antiope Lotsari

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Teknisk ytkemi

Anand Kumar Rajasekharan

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Teknisk ytkemi

Mats Halvarsson

Chalmers, Fysik, Materialens mikrostruktur

Martin Andersson

Martin Andersson Group

Nature Communications

2041-1723 (ISSN)

Vol. 9 4170

Styrkeområden

Nanovetenskap och nanoteknik

Materialvetenskap

Ämneskategorier

Keramteknik

Materialkemi

Biomaterialvetenskap

Medicinska material och protesteknik

DOI

10.1038/s41467-018-06570-x

PubMed

30302020

Mer information

Senast uppdaterat

2018-11-01