Small Variation of Active Pharmaceutical Ingredient Concentration Can Be Observed with THz Frequency Domain Spectroscopy
Paper i proceeding, 2021

Terahertz frequency-domain spectroscopy (THz-FDS) has been employed to study the result of the variation of active pharmaceutical ingredients (API) on the effective refractive index of pharmaceutical tablets. A quasi-optical set-up with four off-axis parabolic mirrors was used to measure the effective refractive index of tablets in the frequency range of 500-750 GHz. It was observed that a small variation in API concentration can be detected using accurate measurements of the complex transmission coefficients. As a result, THz-FDS reveals to be an effective technique in monitoring the physical properties of pharmaceutical tablets

Författare

Anis Moradikouchi

Chalmers, Mikroteknologi och nanovetenskap, Terahertz- och millimetervågsteknik

AstraZeneca R&D

Anders Sparén

AstraZeneca R&D

Staffan Folestad

AstraZeneca R&D

Jan Stake

Chalmers, Mikroteknologi och nanovetenskap, Terahertz- och millimetervågsteknik

Helena Rodilla

Chalmers, Mikroteknologi och nanovetenskap, Terahertz- och millimetervågsteknik

International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz

21622027 (ISSN) 21622035 (eISSN)

Vol. 2021-August
9781728194240 (ISBN)

International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz
Chengdu, China,

Terahertsteknik för tillverkning av moderna läkemedel

Stiftelsen för Strategisk forskning (SSF) (ID17-0011), 2017-12-01 -- 2023-12-31.

Styrkeområden

Informations- och kommunikationsteknik

Materialvetenskap

Infrastruktur

Kollberglaboratoriet

Ämneskategorier

Annan elektroteknik och elektronik

DOI

10.1109/IRMMW-THz50926.2021.9567162

Mer information

Senast uppdaterat

2022-03-10