Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy
Paper i proceeding, 2015
The anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug.
Författare
Murillo L. Martins
Universidade Estadual Paulista (UNESP)
Niels Bohr Institute
A. Orecchini
Universita degli Studi di Perugia
Institut Laue-Langevin
Luis Aguilera Medina
Chalmers, Teknisk fysik, Kondenserade materiens fysik
Juergen Eckert
University of South Florida
J.P. Embs
Paul Scherrer Institut
Aleksandar Matic
Chalmers, Teknisk fysik, Kondenserade materiens fysik
M.J. Saeki
Universidade Estadual Paulista (UNESP)
Heloisa N. Bordallo
Niels Bohr Institute
EPJ Web of Conferences
21016275 (ISSN) 2100014X (eISSN)
Vol. 83 02011
11th International Conference on Quasielastic Neutron Scattering, QENS 2014 and 6th International Workshop on Inelastic Neutron Spectrometers, WINS 2014
Autrans, France,
Autrans, France,
Ämneskategorier
Den kondenserade materiens fysik
DOI
10.1051/epjconf/20158302011