A high-performance lab-on-a-chip liquid sensor employing surface acoustic wave resonance
Artikel i vetenskaplig tidskrift, 2017

We demonstrate herein a new concept for lab-on-a-chip in-liquid sensing, through integration of surface acoustic wave resonance (SAR) in a one-port configuration with a soft polymer microfluidic delivery system. In this concept, the reflective gratings of a one-port surface acoustic wave (SAW) resonator are employed as mass loading-sensing elements, while the SAW transducer is protected from the measurement environment. We describe the design, fabrication, implementation, and characterization using liquid medium. The sensor operates at a frequency of 185 MHz and has demonstrated a comparable sensitivity to other SAW in-liquid sensors, while offering quality factor (Q) value in water of about 250, low impedance and fairly low susceptibility to viscous damping. For proof of principle, sensing performance was evaluated by means of binding 40 nm neutravidin-coated SiO2 nanoparticles to a biotin-labeled lipid bilayer deposited over the reflectors. Frequency shifts were determined for every step of the affinity assay. Demonstration of this integrated technology highlights the potential of SAR technology for in-liquid sensing.

sensor

resonance

integration

microfluidics

surface acoustic waves

Författare

Kiryl Kustanovich

Chalmers, Kemi och kemiteknik, Kemi och biokemi, Fysikalisk kemi

Ventsislav Yantchev

Chalmers, Kemi och kemiteknik, Kemi och biokemi, Fysikalisk kemi

Vladimir Kirejev

Chalmers, Kemi och kemiteknik

Gavin Jeffries

Chalmers, Kemi och kemiteknik

Tatsiana Lobovkina

Chalmers, Kemi och kemiteknik, Kemi och biokemi, Fysikalisk kemi

Aldo Jesorka

Chalmers, Kemi och kemiteknik, Kemi och biokemi, Fysikalisk kemi

Journal of Micromechanics and Microengineering

0960-1317 (ISSN)

Vol. 27 11

Reservoir Computing with Real-time Data for future IT (RECORD-IT)

Europeiska kommissionen (Horisont 2020), 2015-09-01 -- 2018-08-31.

Ämneskategorier

Elektroteknik och elektronik

DOI

10.1088/1361-6439/aa8f21