IFNL4 Genotypes Predict Clearance of RNA Viruses in Rwandan Children With Upper Respiratory Tract Infections
Artikel i vetenskaplig tidskrift, 2019

Polymorphisms in the interferon lambda gene locus (IFNL) such as the IFNL4 genetic variants rs12979860 and rs368234815 are predictive of resolution of hepatitis C virus infection, but information about the impact of these variants in other infections is scarce. This study aimed at determining the potential impact of IFNL4 variation for the clearance of respiratory tract pathogens in Rwandan children (<= 5 years old, n = 480) seeking medical care for acute respiratory infections. Nasopharyngeal swabs were retrieved from all children at the first hospital referral and from 161 children at follow-up visits 2 weeks later. The swabs were analyzed for pathogens by real-time PCR and for host cell IFNL4 genotype at rs12979860 and rs368234815. Approximately 1/3 of the children were homozygous for the rs12979860 T allele and the rs368234815 Delta G allele, which are overrepresented in subjects of African descent. These IFNL4 variants were significantly associated with reduced clearance of RNA viruses. Our results suggest that IFNL4 genotypes that are common among subjects of African descent may determine inefficacious clearance of RNA viruses from the respiratory tract.

upper respiratory tract

single nucleotide polymorphisms

dinucleotide polymorphisms

infection

rs368234815

rs12979860

RNA virus

interferon lambda

Författare

Belson Rugwizangoga

Göteborgs universitet

University of Rwanda

Maria E. Andersson

Göteborgs universitet

Jean-Claude Kabayiza

Göteborgs universitet

University of Rwanda

Malin S. Nilsson

Göteborgs universitet

Brynja Armannsdottir

Göteborgs universitet

Johan Aurelius

Göteborgs universitet

Staffan Nilsson

Chalmers, Matematiska vetenskaper, Tillämpad matematik och statistik

Göteborgs universitet

Kristoffer Hellstrand

Göteborgs universitet

Magnus Lindh

Göteborgs universitet

Anna Martner

Göteborgs universitet

Frontiers in cellular and infection microbiology

2235-2988 (ISSN)

Vol. 9 340

Ämneskategorier

Pediatrik

Infektionsmedicin

Mikrobiologi inom det medicinska området

DOI

10.3389/fcimb.2019.00340

PubMed

31637221

Mer information

Senast uppdaterat

2020-04-14