Multidisciplinary evaluation of the cancer risk from neutrons relative to photons using stem cells and the induction of second malignant neoplasms following paediatric radiation therapy (ANDANTE)

The ANDANTE project will investigate the relative risk of neutrons compared to photons for tumourigenesis, as a function of dose and energy. The approach will be multidisciplinary, including physics measurements and modelling, molecular biology, radiobiology, and epidemiology. The relative risk of neutrons will be studied using human and animal stem cells irradiated with either photons or neutrons in vitro and analysed for early indicators of malignant transformations. Irradiated stem cells will be transplanted into mice to investigate progression into tumours. The experimental irradiation setup will be fully characterised and modelled in order to compare predicted molecular damage with biological results, following trolled irradiation with either photons or neutrons. A corresponding predictive model of the relative risk of cancer induction from photons or neutrons following paediatric radiotherapy will be developed and tested on clinical data, as a proof of principle, leading to a proposal for a prospective epidemiological study to validate the relative risk of neutrons on humans.

Participants

Lembit Sihver (contact)

Professor vid Nuclear Engineering

Collaborations

Academisch Ziekenhuis Groningen

Groningen, Netherlands

Bundesamt für Strahlenschutz

Salzgitter, Germany

European Society For Therapeutic Radiology And Oncology (ESTRO)

Brussels, Belgium

Loma Linda University

Loma Linda, USA

Paul Scherrer Institut

Villigen Psi, Switzerland

Universita degli studi di Pavia

Pavia, Italy

Universitaet Rostock

Rostock, Germany

Funding

European Commission (FP7)

Funding Chalmers participation during 2012–2015

More information

Project Web Page

www.andanteproject.eu

Created

2014-11-20