Simulations of lipid transfer between a supported lipid bilayer and adsorbing vesicles
Journal article, 2010

Recent experiments demonstrate transfer of lipid molecules between a charged, supported lipid membrane (SLB) and vesicles of opposite charge when the latter adsorb on the SLB. A simple phenomenological bead model has been developed to simulate this process. Beads were defined to be of three types, 'n', 'p', and '0', representing POPS (negatively charged), POEPC (positively charged), and POPC (neutral but zwitterionic) lipids, respectively. Phenomenological bead-bead interaction potentials and lipid transfer rate constants were used to account for the overall interaction and transfer kinetics. Using different bead mixtures in both the adsorbing vesicle and in the SLB (representing differently composed/charged vesicles and SLBs as in the reported experiments), we clarify under which circumstances a vesicle adsorbs to the SLB, and whether it, after lipid transfer and changed composition of the SLB and vesicle, desorbs back to the bulk again or not. With this model we can reproduce and provide a conceptual picture for the experimental findings

supported lipid bilayer

Lipid transfer

lipid mixture

lipid exchange

vesicle adsorption

Monte Carlo simulation

vesicle-lipid bilayer interactions

Author

Kristian Dimitrievski

Chalmers, Applied Physics, Chemical Physics

Bengt Herbert Kasemo

Chalmers, Applied Physics, Chemical Physics

Colloids and Surfaces B: Biointerfaces

0927-7765 (ISSN)

Vol. 75 2 454-465

Subject Categories

Atom and Molecular Physics and Optics

Other Physics Topics

DOI

10.1016/j.colsurfb.2009.09.019

More information

Created

10/7/2017