Hierarchical genetic networks and noncoding RNAs
Journal article, 2010
In eukaryotic cells, many genes are transcribed into noncoding RNAs. Such RNAs may associate with mRNAs and inhibit their translation and facilitate degradation. To clarify what may happen in this case, we propose a kinetic model describing the effect of noncoding RNAs on a mRNA-protein network with the hierarchical three-layer architecture. For positive regulation of the layers, our model predicts either bistability with a fairly narrow hysteresis loop or a unique steady state. For negative or mixed regulation, the steady state is found to be unique.
coding rna
expression
transcriptional regulatory network
oscillations
distinct messenger-rnas
protein
microrna regulation
nonprotein
escherichia-coli
decay-rates
bistability
Author
Vladimir Zhdanov
Chalmers, Applied Physics, Chemical Physics
Chaos
1054-1500 (ISSN) 1089-7682 (eISSN)
Vol. 20 4 045112Subject Categories
Computational Mathematics
Physical Sciences
DOI
10.1063/1.3528001