Hierarchical genetic networks and noncoding RNAs
Journal article, 2010

In eukaryotic cells, many genes are transcribed into noncoding RNAs. Such RNAs may associate with mRNAs and inhibit their translation and facilitate degradation. To clarify what may happen in this case, we propose a kinetic model describing the effect of noncoding RNAs on a mRNA-protein network with the hierarchical three-layer architecture. For positive regulation of the layers, our model predicts either bistability with a fairly narrow hysteresis loop or a unique steady state. For negative or mixed regulation, the steady state is found to be unique.

coding rna

expression

transcriptional regulatory network

oscillations

distinct messenger-rnas

protein

microrna regulation

nonprotein

escherichia-coli

decay-rates

bistability

Author

Vladimir Zhdanov

Chalmers, Applied Physics, Chemical Physics

Chaos

1054-1500 (ISSN) 1089-7682 (eISSN)

Vol. 20 4

Subject Categories

Computational Mathematics

Physical Sciences

DOI

10.1063/1.3528001

More information

Created

10/7/2017