Liver-derived igf-I regulates mean life span in mice
Journal article, 2011
Transgenic mice with low levels of global insulin-like growth factor-I (IGF-I) throughout their life span, including pre- and postnatal development, have increased longevity. This study investigated whether specific deficiency of liver-derived, endocrine IGF-I is of importance for life span.
Author
Johan Svensson
University of Gothenburg
Klara Sjögren
University of Gothenburg
Jenny Fäldt
University of Gothenburg
Niklas Andersson
University of Gothenburg
Chalmers, Chemical and Biological Engineering, Life Sciences
Olle Isaksson
University of Gothenburg
John-Olov Jansson
University of Gothenburg
Claes Ohlsson
University of Gothenburg
PLoS ONE
1932-6203 (ISSN) 19326203 (eISSN)
Vol. 6 7 e22640- e22640Subject Categories
Endocrinology and Diabetes
MEDICAL AND HEALTH SCIENCES
DOI
10.1371/journal.pone.0022640
PubMed
21799924