Interplay of viral miRNAs and host mRNAs and proteins
Journal article, 2011
Recent experiments indicate that several viruses may encode microRNAs (miRNAs) in cells. Such RNAs may interfere with the host mRNAs and proteins. We present a kinetic analysis of this interplay. In our treatment, the viral miRNA is considered to be able to associate with the host mRNA with subsequent degradation. This process may result in a decline of the mRNA population and also in a decline of the population of the protein encoded by this mRNA. With these ingredients, we first show the types of the corresponding steady-state kinetics in the cases of positive and negative regulation of the miRNA synthesis by the protein. In addition, we scrutinize the situation when the protein regulates the virion replication or, in other words, provides a feedback for the replication. For the negative feedback, the replication rate is found to increase with increasing the intracellular virion population. For the positive feedback, the replication rate first increases and then drops. These features may determine the stability of steady states.
model
processes
infection
dynamics
nonlinear dynamics
degradation
vaccine production
mRNA
miRNA and protein synthesis and
influenza-virus replication
bistability
equations
micrornas
bifurcation
challenges
viral replication
long noncoding rnas
kinetics
subcellular processes
mean-field kinetic
to-cell spread
Author
Vladimir Zhdanov
Chalmers, Applied Physics, Chemical Physics
Central European Journal of Physics
1895-1082 (ISSN) 1644-3608 (eISSN)
Vol. 9 5 1366-1371Subject Categories
Physical Sciences
DOI
10.2478/s11534-011-0054-z