Impaired thymic export and apoptosis contribute to regulatory T-cell defects in patients with chronic heart failure.
Journal article, 2011
Animal studies suggest that regulatory T (T(reg)) cells play a beneficial role in ventricular remodeling and our previous data have demonstrated defects of T(reg) cells in patients with chronic heart failure (CHF). However, the mechanisms behind T(reg-)cell defects remained unknown. We here sought to elucidate the mechanism of T(reg-)cell defects in CHF patients.
immune system
heart
Author
Ting-Ting Tang
Zheng-Feng Zhu
Jun Wang
Wen-Cai Zhang
Xin Tu
Hong Xiao
Xin-Ling Du
Jia-Hong Xia
Nian-Guo Dong
Wei Su
Ni Xia
Xing-Xing Yan
Shao-Fang Nie
Juan Liu
Su-Feng Zhou
Rui Yao
Jiang-Jiao Xie
Harish Jevallee
Xiang Wang
Meng-Yang Liao
Guo-Ping Shi
Michael Fu
Yu-Hua Liao
Xiang Cheng
PLoS ONE
1932-6203 (ISSN) 19326203 (eISSN)
Vol. 6 9 e24272-Subject Categories
Dermatology and Venereal Diseases
Physiology
Microbiology in the medical area
DOI
10.1371/journal.pone.0024272
PubMed
21935395