Inhibition of the receptor-mediated virion attachment to a lipid membrane
Journal article, 2012
The forefront of the anti-viral defence is sometimes aimed at virion attachment to a host membrane. This step or, more specifically, virion contacts with cellular membrane receptors (or, e.g., glycolipids) can be inhibited by antibodies (or specially chosen or designed compounds) via their association with virions. In this case, the full-scale attachment of virions to a host membrane occurs via a subtle interplay of the formation and rupture of multiple virion-inhibitor and virion-receptor bonds. We present a kinetic model describing this interplay and illustrating general trends in the process under consideration.
infection
endocytosis
enveloped viruses
viral entry
mechanisms
neutralization
virology
antibody therapeutics
entry
mean-field kinetic equations
Author
Vladimir Zhdanov
Chalmers, Applied Physics, Chemical Physics
Central European Journal of Physics
1895-1082 (ISSN) 1644-3608 (eISSN)
Vol. 10 5 1210-1215Hydrodynamic concentration of native membrane proteins for on-chip functional studies
Swedish Research Council (VR) (2010-5063), 2011-01-01 -- 2014-12-31.
Subject Categories
Physical Sciences
DOI
10.2478/s11534-012-0119-7