Selective cleavage of 3,5-bis-(trifluoromethyl)benzylcarbamate by SmI2-Et3N-H2O
Journal article, 2013
A novel electron poor protection group for amines has been developed. It undergoes rapid cleavage by SmI2-Et3N-H2O and its orthogonality towards the regular benzyl carbamate group (CBz) under reductive or transfer hydrogenolytic conditions is reported.
diiodosamarium
organic-chemistry
additives
amino-protecting group
alcohols
reagent
reductions
peptide-synthesis
deprotection
samarium(ii) iodide
Author
Tobias Ankner
University of Gothenburg
Anna Said Stålsmeden
University of Gothenburg
Göran Hilmersson
University of Gothenburg
Chemical Communications
1359-7345 (ISSN) 1364-548X (eISSN)
Vol. 49 61 6867-6869Subject Categories
Organic Chemistry
DOI
10.1039/c3cc41642a