Selective cleavage of 3,5-bis-(trifluoromethyl)benzylcarbamate by SmI2-Et3N-H2O
Journal article, 2013

A novel electron poor protection group for amines has been developed. It undergoes rapid cleavage by SmI2-Et3N-H2O and its orthogonality towards the regular benzyl carbamate group (CBz) under reductive or transfer hydrogenolytic conditions is reported.

diiodosamarium

organic-chemistry

additives

amino-protecting group

alcohols

reagent

reductions

peptide-synthesis

deprotection

samarium(ii) iodide

Author

Tobias Ankner

University of Gothenburg

Anna Said Stålsmeden

University of Gothenburg

Göran Hilmersson

University of Gothenburg

Chemical Communications

1359-7345 (ISSN)

Vol. 49 61 6867-6869

Subject Categories

Organic Chemistry

DOI

10.1039/c3cc41642a

More information

Created

10/10/2017