ATP Hydrolysis in the RecA-DNA Filament Promotes Structural Changes at the Protein-DNA Interface
Journal article, 2015

To address the mechanistic roles of ATP hydrolysis in RecA-promoted strand exchange reaction in homologous recombination, quantum mechanical calculations are performed on key parts of the RecA-DNA complex. We find that ATP hydrolysis may induce changes at the protein-DNA interface, resulting in the rearrangement of the hydrogen bond network connecting the ATP and the DNA binding sites.

Author

Anna Reymer

University of Gothenburg

Sandor Babik

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Physical Chemistry

M. Takahashi

Tokyo Institute of Technology

Bengt Nordén

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Physical Chemistry

Tamas Beke-Somfai

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Physical Chemistry

Biochemistry

0006-2960 (ISSN) 1520-4995 (eISSN)

Vol. 54 30 4579-4582

Subject Categories

Physical Chemistry

Organic Chemistry

DOI

10.1021/acs.biochem.5b00614

PubMed

26196253

More information

Latest update

2/21/2018