Long-term osseointegration of 3D printed CoCr constructs with an interconnected open-pore architecture prepared by electron beam melting.
Journal article, 2016

In orthopaedic surgery, cobalt chromium (CoCr) based alloys are used extensively for their high strength and wear properties, but with concerns over stress shielding and bone resorption due to the high stiffness of CoCr. The structural stiffness, principally related to the bulk and the elastic modulus of the material, may be lowered by appropriate design modifications, to reduce the stiffness mismatch between metal/alloy implants and the adjacent bone. Here, 3D printed CoCr and Ti6Al4V implants of similar macro-geometry and interconnected open-pore architecture prepared by electron beam melting (EBM) were evaluated following 26week implantation in adult sheep femora. Despite higher total bone-implant contact for Ti6Al4V (39±4%) than CoCr (27±4%), bone formation patterns were similar, e.g., densification around the implant, and gradual ingrowth into the porous network, with more bone in the outer half (periphery) than the inner half (centre). Raman spectroscopy revealed no major differences in mineral crystallinity, the apatite-to-collagen ratio, or the carbonate-to-phosphate ratio. Energy dispersive X-ray spectroscopy showed similar Ca/P ratio of the interfacial tissue adjacent to both materials. Osteocytes made direct contact with CoCr and Ti6Al4V. While osteocyte density and distribution in the new-formed bone were largely similar for the two alloys, higher osteocyte density was observed at the periphery of the porous network for CoCr, attributable to slower remodelling and a different biomechanical environment. The results demonstrate the possibility to achieve bone ingrowth into open-pore CoCr constructs, and attest to the potential for fabricating customised osseointegrated CoCr implants for load-bearing applications.

Titanium

Additive manufacturing

3D printing

Electron beam melting

Alloy

Osseointegration

Cobalt chromium

Author

Furqan A. Shah

University of Gothenburg

Omar Omar

University of Gothenburg

Felicia Suska

University of Gothenburg

Anders Snis

BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy

Aleksandar Matic

Chalmers, Physics, Condensed Matter Physics

Lena Emanuelsson

University of Gothenburg

Birgitta Norlindh

University of Gothenburg

Jukka Lausmaa

SP Sveriges Tekniska Forskningsinstitut AB

BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy

Peter Thomsen

University of Gothenburg

Anders Palmquist

University of Gothenburg

Acta Biomaterialia

1742-7061 (ISSN)

Vol. 36 May 296-309

Subject Categories

Dentistry

Areas of Advance

Materials Science

DOI

10.1016/j.actbio.2016.03.033

PubMed

27000553

More information

Latest update

9/6/2018 1