Direct Highly Regioselective Functionalization of Carbohydrates: A Three-Component Reaction Combining the Dissolving and Catalytic Efficiency of Ionic Liquids
Journal article, 2016
An unprecedented regioselective functionalization of unprotected polyols has been realized with the use of an ionic liquid NHC precatalyst. The protocol is robust, scalable, and the products can be isolated in good to excellent yields without chromatography. Moreover, the methodology enables successful recycling of the catalyst.
multicomponent reaction
Regioselectivity
NHC
Organocatalysis
Ionic liquids
Carbohydrates
Author
Anton Axelsson
Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry
Linda Ta
Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry
Henrik Sundén
Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry
European Journal of Organic Chemistry
1434-193X (ISSN) 10990690 (eISSN)
Vol. 2016 20 3339-3343Subject Categories
Organic Chemistry
DOI
10.1002/ejoc.201600536