Direct Highly Regioselective Functionalization of Carbohydrates: A Three-Component Reaction Combining the Dissolving and Catalytic Efficiency of Ionic Liquids
Journal article, 2016

An unprecedented regioselective functionalization of unprotected polyols has been realized with the use of an ionic liquid NHC precatalyst. The protocol is robust, scalable, and the products can be isolated in good to excellent yields without chromatography. Moreover, the methodology enables successful recycling of the catalyst.

multicomponent reaction

Regioselectivity

NHC

Organocatalysis

Ionic liquids

Carbohydrates

Author

Anton Axelsson

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Organic Chemistry

Linda Ta

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Organic Chemistry

Henrik Sundén

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Organic Chemistry

European Journal of Organic Chemistry

1434-193X (ISSN)

Vol. 2016 3339-3343

Subject Categories

Organic Chemistry

DOI

10.1002/ejoc.201600536