Enhanced growth of neural networks on cellulose-derived carbon nanofibrous scaffolds
Paper in proceedings, 2015

Tissue engineering is a prospective method for solving the problem of recovery from neurodegenerative disorders as it helps to grow healthy neural tissue using supportive scaffolds. Biocompatible scaffolds with mechanical stability, appropriate topography and electrical conductivity previously demonstrated efficient results in neural tissue engineering applications. In this study, we present sustainable cellulose-derived carbon nanofibrous (CNF) biomaterial that can be used either as a scaffold for the regeneration of neural tissue or as a drug screening model. This scaffold material was characterized with excellent biocompatibility (95.6% cell viability), nanosized topography (fiber diameter in the range of 50-250 nm) and electrical conductivity (10*7 times higher value than the one of an unmodified cellulosic precursor) to support adhesion, growth and differentiation of SH-SY5Y neuroblastoma cells. The results showed that the formation of a neural network occurred within 10 days of differentiation, which is a good duration for SH-SY5Y neuroblastoma cells. We can conclude that topography and electrical conductivity of the CNF material played a major role in its positive influence on the development of neural tissue. CNF nanotopography resembles the one of an extracellular matrix of neural tissue, while electrical conductivity allows utilization of electrochemical signals for information transmission between neurons.

Author

Volodymyr Kuzmenko

Chalmers, Applied Physics, Electronics Material and Systems Laboratory

Theodoros Kalogeropoulos

Chalmers, Chemistry and Chemical Engineering

Johannes Thunberg

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Organic Chemistry

Sara Johannesson

Chalmers, Chemistry and Chemical Engineering

Daniel Hägg

Chalmers, Chemistry and Chemical Engineering, Applied Chemistry, Polymer Technology

Peter Enoksson

Chalmers, Applied Physics, Electronics Material and Systems Laboratory

Wallenberg Wood Science Center (WWSC)

Paul Gatenholm

Chalmers, Chemistry and Chemical Engineering, Applied Chemistry, Polymer Technology

Wallenberg Wood Science Center (WWSC)

Annual World Conference on Carbon – CARBON 2015

Driving Forces

Sustainable development

Subject Categories

Manufacturing, Surface and Joining Technology

Other Materials Engineering

Biomaterials Science

Nano Technology

Infrastructure

Nanofabrication Laboratory

Areas of Advance

Materials Science

More information

Latest update

9/21/2018