Long-Lived Trifluoromethanide Anion: A Key Intermediate in Nucleophilic Trifluoromethylations.
Journal article, 2014

The trifluoromethanide anion is the postulated key intermediate in nucleophilic trifluoromethylation reactions. However, for more than six decades, the trifluoromethanide anion was widely believed to exist only as a short-lived transient species in the condensed phase. It has now been prepd. in bulk for the first time in THF soln. The trifluoromethanide anion with the [K(18-crown-6)]+ cation was unequivocally characterized by low-temp. 19F and 13C NMR spectroscopy. Its intermediacy in nucleophilic trifluoromethylation reactions was directly evident by its reaction chem. with various electrophilic substrates. Variable-temp. NMR spectroscopy, along with quantum mech. calcns., support the persistence of the trifluoromethanide anion. [on SciFinder(R)]


reaction mechanisms

reactive intermediates

NMR spectroscopy



G. K. Surya Prakash

F. Wang

Zhe Zhang

Ralf Haiges

Karl O. Christe

Thomas Mathew

George A. Olah

Angewandte Chemie - International Edition

1433-7851 (ISSN) 1521-3773 (eISSN)

Vol. 53 43 11575-11578

Subject Categories

Inorganic Chemistry

Theoretical Chemistry

Organic Chemistry



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