Development of a sensitive induction-based magnetic nanoparticle biodetection method
Journal article, 2018

We developed a novel biodetection method for influenza virus based on AC magnetic susceptibility measurement techniques (the DynoMag induction technique) together with functionalized multi-core magnetic nanoparticles. The sample consisting of an incubated mixture of magnetic nanoparticles and rolling circle amplified DNA coils is injected into a tube by a peristaltic pump. The sample is moved as a plug to the two well-balanced detection coils and the dynamic magnetic moment in each position is read over a range of excitation frequencies. The time for making a complete frequency sweep over the relaxation peak is about 5 minutes (10 Hz–10 kHz with 20 data points). The obtained standard deviation of the magnetic signal at the relaxation frequency (around 100 Hz) is equal to about 10−5 (volume susceptibility SI units), which is in the same range obtained with the DynoMag system. The limit of detection with this method is found to be in the range of 1 pM.

Multi-core particles

AC susceptibility

Brownian relaxation

Magnetic nanoparticles

Magnetic biosensing

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Published in

Nanomaterials

20794991 (eISSN)

Vol. 8 Issue 11 art. no 887

Research Project(s)

Point-of care Influenza Diagnostics FLU-ID

Swedish Foundation for Strategic Research (SSF) (SBE13-0125), 2014-06-01 -- 2020-12-31.

Swedish Foundation for Strategic Research (SSF) (SBE13-0125), 2021-01-01 -- 2021-03-31.

Categorizing

Subject Categories (SSIF 2011)

Analytical Chemistry

Other Electrical Engineering, Electronic Engineering, Information Engineering

Condensed Matter Physics

Identifiers

DOI

10.3390/nano8110887

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1/3/2024 9