Development of a sensitive induction-based magnetic nanoparticle biodetection method
Journal article, 2018

We developed a novel biodetection method for influenza virus based on AC magnetic susceptibility measurement techniques (the DynoMag induction technique) together with functionalized multi-core magnetic nanoparticles. The sample consisting of an incubated mixture of magnetic nanoparticles and rolling circle amplified DNA coils is injected into a tube by a peristaltic pump. The sample is moved as a plug to the two well-balanced detection coils and the dynamic magnetic moment in each position is read over a range of excitation frequencies. The time for making a complete frequency sweep over the relaxation peak is about 5 minutes (10 Hz–10 kHz with 20 data points). The obtained standard deviation of the magnetic signal at the relaxation frequency (around 100 Hz) is equal to about 10−5 (volume susceptibility SI units), which is in the same range obtained with the DynoMag system. The limit of detection with this method is found to be in the range of 1 pM.

Brownian relaxation

AC susceptibility

Magnetic nanoparticles

Multi-core particles

Magnetic biosensing

Author

Jakob Blomgren

RISE Acreo

Fredrik Ahrentorp

RISE Acreo

Dag Ilver

RISE Acreo

Christian Jonasson

RISE Acreo

Sobhan Sepehri

Chalmers, Microtechnology and Nanoscience (MC2), Quantum Device Physics

Alexei Kalaboukhov

Chalmers, Microtechnology and Nanoscience (MC2), Quantum Device Physics

Dag Winkler

Chalmers, Microtechnology and Nanoscience (MC2), Quantum Device Physics

Teresa Zardán Gómez de la Torre

Uppsala University

Maria Strømme

Uppsala University

C. Johansson

RISE Acreo

Nanomaterials

20794991 (eISSN)

Vol. 8 11 887

Point-of care Influenza Diagnostics FLU-ID

Swedish Foundation for Strategic Research (SSF), 2014-06-01 -- 2019-05-31.

Subject Categories

Analytical Chemistry

Other Electrical Engineering, Electronic Engineering, Information Engineering

Condensed Matter Physics

DOI

10.3390/nano8110887

More information

Latest update

8/13/2019