Spray Dried Smectite Clay Particles as a Novel Treatment against Obesity
Journal article, 2019
Methods: Spray dried montmorillonite (SD-MMT) and spray dried laponite (SD-LAP) particles were prepared via spray drying. Particle morphology, surface area and redispersion/aggregation properties in aqueous media were characterized. The ability of SD-MMT and SD-LAP particles to inhibit lipid digestion kinetics and adsorb lipid species from solution was assessed during in vitro lipolysis using proton nuclear magnetic resonance analysis. SD-MMT and SD-LAP particles were dosed to rodents fed a high-fat diet and their effect on body weight gain was evaluated.
Results: Both SD-MMT and SD-LAP particles adsorbed significant quantities of medium chain triglycerides and lipolytic products from solution during in vitro lipolysis. At a concentration of 50% w/w relative to lipid content, SD-MMT and SD-LAP particles adsorbed 42% and 94% of all lipid species, respectively. SD-MMT and SD-LAP particles also reduced the extent of rodent weight gain relative to the negative control treatment group and performed similarly to orlistat via an alternate mechanism of action.
Conclusions: Spray dried smectite clay particles (SD-MMT and SD-LAP) with significant adsorptive capacities for dietary lipids and digestion products were successfully fabricated. These particles may be developed as novel anti-obesity treatments with fewer adverse effects than currently marketed treatment options.
laponite
digestion
lipid
obesity
montmorillonite
Author
Tahnee J. Dening
University of South Australia
Paul Joyce
University of South Australia
Miia Kovalainen
University of South Australia
University of Oulu
Hanna Gustafsson
Chalmers, Physics, Biological Physics
University of South Australia
Clive A. Prestidge
University of South Australia
Pharmaceutical Research
0724-8741 (ISSN) 1573-904X (eISSN)
Vol. 36 1 21Subject Categories
Food Engineering
Materials Chemistry
Other Chemistry Topics
DOI
10.1007/s11095-018-2552-9