Slow relaxation during and after perturbation of bistable kinetics of gene expression
Journal article, 2019

After a short perturbation of a bistable genetic network, it returns to its initial steady state or transits to another steady state. The time scale characterizing such transient regimes can be appreciably longer compared to those of the degradation of the perturbed mRNAs and proteins. The author shows in detail the specifics of this slowdown of the transient kinetics using mean-field kinetic equations and Monte Carlo simulations. Attention is focused on nanocarrier-mediated delivery and release of short non-coding RNA (e.g., miRNA or siRNA) into cells with subsequent suppression of the populations of the targeted mRNA and corresponding protein.

Transient kinetics

Gene expression

Drug delivery

Bistability

Mean-field kinetic equations

Monte Carlo simulations

Author

Vladimir Zhdanov

Chalmers, Physics, Biological Physics

European Biophysics Journal

0175-7571 (ISSN) 1432-1017 (eISSN)

Vol. 48 3 297-302

Subject Categories

Biochemistry and Molecular Biology

Cell and Molecular Biology

Biophysics

DOI

10.1007/s00249-019-01358-3

PubMed

30903265

More information

Latest update

8/19/2019