Metabolic engineering for increased lipid accumulation in Yarrowia lipolytica – A Review
Review article, 2020

Current energy security and climate change policies encourage the development and utilization of bioenergy. Oleaginous yeasts provide a particularly attractive platform for the sustainable production of biofuels and industrial chemicals due to their ability to accumulate high amounts of lipids. In particular, microbial lipids in the form of triacylglycerides (TAGs) produced from renewable feedstocks have attracted considerable attention because they can be directly used in the production of biodiesel and oleochemicals analogous to petrochemicals. As an oleaginous yeast that is generally regarded as safe, Yarrowia lipolytica has been extensively studied, with large amounts of data on its lipid metabolism, genetic tools, and genome sequencing and annotation. In this review, we highlight the newest strategies for increasing lipid accumulation using metabolic engineering and summarize the research advances on the overaccumulation of lipids in Y. lipolytica. Finally, perspectives for future engineering approaches are proposed.



Yarrowia lipolytica

Lipid accumulation

Metabolic engineering


Jinpeng Wang

Nanjing Tech University

R. Ledesma-Amaro

Imperial College London

Yongjun Wei

Zhengzhou University

Boyang Ji

Technical University of Denmark (DTU)

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Xiao Jun Ji

Nanjing Tech University

Bioresource Technology

0960-8524 (ISSN) 1873-2976 (eISSN)

Vol. 313 123707

Subject Categories

Social Sciences Interdisciplinary

Renewable Bioenergy Research

Energy Systems





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9/1/2020 7