Graphene, other carbon nanomaterials and the immune system: toward nanoimmunity-by-design
Journal article, 2020

Carbon-based materials (CBMs), such as graphene, nanodiamonds, carbon fibers, and carbon dots, have attracted a great deal scientific attention due to their potential as biomedical tools. Following exposure, particularly intravenous injection, these nanomaterials can be recognized by immune cells. Such interactions could be modulated by the different physicochemical properties of the materials (e.g. structure, size, and chemical functions), by either stimulating or suppressing the immune response. However, a harmonized cutting-edge approach for the classification of these materials based not only on their physicochemical parameters but also their immune properties has been missing. The European Commission-funded G-IMMUNOMICS and CARBO-IMmap projects aimed to fill this gap, developing a functional pipeline for the qualitative and quantitative immune characterization of graphene, graphene-related materials (GRMs), and other CBMs. The goal was to open breakthrough perspectives for the definition of the immune profiles of these materials. Here, we summarize our methodological approach, key results, and the necessary multidisciplinary expertise ranging across various fields, from material chemistry to engineering, immunology, toxicology, and systems biology. G-IMMUNOMICS, as a partnering project of the Graphene Flagship, the largest scientific research initiative on graphene worldwide, also complemented the studies performed in the Flagship on health and environmental impact of GRMs. Finally, we present the nanoimmunity-by-design concept, developed within the projects, which can be readily applied to other 2D materials. Overall, the G-IMMUNOMICS and CARBO-IMmap projects have provided new insights on the immune impact of GRMs and CBMs, thus laying the foundation for their safe use and future translation in medicine.

graphene

nanotoxicology

nanosafety

nanomedicine

systems biology

carbon nanotubes

single cell mass cytometry

Author

Arianna Gazzi

University of Trieste

Basque Foundation for Science (Ikerbasque)

Fdn Ist Ric Pediat

Laura Fusco

Sidra Medicine

University of Trieste

Basque Foundation for Science (Ikerbasque)

Fdn Ist Ric Pediat

Marco Orecchioni

University of Sassari

La Jolla Inst Immunol, Div Inflammat Biol

Silvia Ferrari

University of Sassari

Giulia Franzoni

Ist Zooprofilatt Sperimentale Sardegna

J. Stephen Yan

Rice University

Matthias Rieckher

University of Cologne

Guotao Peng

Karolinska Institutet

Matteo Andrea Lucherelli

University of Strasbourg

Isabella Anna Vacchi

University of Strasbourg

Ngoc Do Quyen Chau

University of Strasbourg

Alejandro Criado

Centro de Investigación Cooperativa en Biomateriales CIC biomaGUNE

Akcan Istif

University of Trieste

Donato Mancino

Centro de Investigación Cooperativa en Biomateriales CIC biomaGUNE

Antonio Dominguez

Centro de Investigación Cooperativa en Biomateriales CIC biomaGUNE

Hagen Eckert

Technische Universität Dresden

Ester Vazquez

University of Castilla, La Mancha

Tatiana Da Ros

University of Trieste

Paola Nicolussi

Ist Zooprofilatt Sperimentale Sardegna

Vincenzo Palermo

Chalmers, Industrial and Materials Science, Materials and manufacture

Bjoern Schumacher

University of Cologne

Gianaurelio Cuniberti

Technische Universität Dresden

Yiyong Mai

Shanghai Jiao Tong University

Cecilia Clementi

Rice University

Matteo Pasquali

Rice University

Xinliang Feng

Technische Universität Dresden

Kostas Kostarelos

Catalan Institute of Nanoscience and Nanotechnology (ICN2)

University of Manchester

Acelya Yilmazer

Ankara Universitesi

Davide Bedognetti

Sidra Medicine

Bengt Fadeel

Karolinska Institutet

Maurizio Prato

University of Trieste

Centro de Investigación Cooperativa en Biomateriales CIC biomaGUNE

Basque Foundation for Science (Ikerbasque)

Alberto Bianco

University of Strasbourg

Lucia Gemma Delogu

Fdn Ist Ric Pediat

University of Sassari

University of Padua

JOURNAL OF PHYSICS-MATERIALS

2515-7639 (eISSN)

Vol. 3 3 034009

Subject Categories

Other Engineering and Technologies not elsewhere specified

Textile, Rubber and Polymeric Materials

Composite Science and Engineering

DOI

10.1088/2515-7639/ab9317

More information

Latest update

9/25/2020