Injectable conductive hydrogel restores conduction through ablated myocardium
Journal article, 2020

Introduction Therapies for substrate-related arrhythmias include ablation or drugs targeted at altering conductive properties or disruption of slow zones in heterogeneous myocardium. Conductive compounds such as carbon nanotubes may provide a novel personalizable therapy for arrhythmia treatment by allowing tissue homogenization.
Methods A nanocellulose carbon nanotube-conductive hydrogel was developed to have conduction properties similar to normal myocardium. Ex vivo perfused canine hearts were studied. Electroanatomic activation mapping of the epicardial surface was performed at baseline, after radiofrequency ablation, and after uniform needle injections of the conductive hydrogel through the injured tissue. Gross histology was used to assess distribution of conductive hydrogel in the tissue.
Results The conductive hydrogel viscosity was optimized to decrease with increasing shear rate to allow expression through a syringe. The direct current conductivity under aqueous conduction was 4.3 x 10(-1) S/cm. In four canine hearts, when compared with the homogeneous baseline conduction, isochronal maps demonstrated sequential myocardial activation with a shift in direction of activation to surround the edges of the ablated region. After injection of the conductive hydrogel, isochrones demonstrated conduction through the ablated tissue with activation restored through the ablated tissue. Gross specimen examination demonstrated retention of the hydrogel within the tissue.
Conclusions This proof-of-concept study demonstrates that conductive hydrogel can be injected into acutely disrupted myocardium to restore conduction. Future experiments should focus on evaluating long-term retention and biocompatibility of the hydrogel through in vivo experimentation.

carbon nanotubes

injectable hydrogel

translational research

electroanatomic mapping



Martin van Zyl

Mayo Clinic

Dawn M. Pedrotty

University of Pennsylvania

Erdem Karabulut

Chalmers, Chemistry and Chemical Engineering, Applied Chemistry

Volodymyr Kuzmenko

Chalmers, Microtechnology and Nanoscience (MC2), Electronics Material and Systems

Sanna Sämfors

Chalmers, Chemistry and Chemical Engineering, Applied Chemistry

Christopher Livia

Mayo Clinic

Vaibhav Vaidya

Mayo Clinic

Alan Sugrue

Mayo Clinic

Christopher J. McLeod

Mayo Clinic

Atta Behfar

Mayo Clinic

Samuel J. Asirvatham

Mayo Clinic

Paul Gatenholm

Chalmers, Chemistry and Chemical Engineering, Applied Chemistry

Suraj Kapa

Mayo Clinic

Journal of Cardiovascular Electrophysiology

1045-3873 (ISSN) 1540-8167 (eISSN)

Vol. 31 12 3293-3301

Subject Categories

Textile, Rubber and Polymeric Materials

Medical Biotechnology

Biomaterials Science





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