Microbial profiling identifies potential key drivers in gastric cancer patients
Journal article, 2021

Gastric cancer (GC) is the fifth most commonly diagnosed cancer and the third leading cause of cancer-related death in the world. Microbiota is believed to be associated with GC. Growing evidences showed Helicobacter pylori played a key role in GC development. However, little was known about the microbiota in gastric juices and tissues in GC patients, and thus it was difficult to understand other potential microbial causation for GC. Here, we collected the gastric juice and surgically removed gastric tissues from GC patients to give insight into GC microbiota. Most microbes identified in the gastric samples were opportunistic pathogens or resident flora of the human microbiota. Further network analyses identified five opportunistic pathogens as keystone species. H. pylori is the direct cause of GC, but other opportunistic microbes might also function in GC development. The microbiota in the gastric juice and gastric tissue of the GC patients were complex, and some dominant opportunistic pathogens contributed to the GC development. This study introduces microbiota in gastric juice, gastric normal tissue and gastric cancer tissue of GC patients, and highlights the potential keystone microbes functioned during GC development.


opportunistic pathogens

Helicobacter pylori

network analysis

Gastric cancer


Yonghong Li

Zhengzhou University

Jia Wang

Zhengzhou University

Mengge Wang

Zhengzhou University

Yongshun Gao

Zhengzhou University

Cheng-Yun Jin

Zhengzhou University

Xiaojing Shi

Zhengzhou University

Boyang Ji

Technical University of Denmark (DTU)

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Yongjun Wei

Zhengzhou University

Hongmin Liu

Zhengzhou University

Biotechnology and Biotechnological Equipment

1310-2818 (ISSN)

Vol. 35 1 496-503

Subject Categories

Gastroenterology and Hepatology

Microbiology in the medical area

Cancer and Oncology



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