Impact of hydrogen peroxide on protein synthesis in yeast
Review article, 2021

Cells must be able to respond and adapt to different stress conditions to maintain normal function. A common response to stress is the global inhibition of protein synthesis. Protein synthesis is an expensive process consuming much of the cell’s energy. Consequently, it must be tightly regulated to conserve resources. One of these stress conditions is oxidative stress, resulting from the accumulation of reactive oxygen species (ROS) mainly produced by the mitochondria but also by other intracellular sources. Cells utilize a variety of antioxidant systems to protect against ROS, directing signaling and adaptation responses at lower levels and/or detoxification as levels increase to preclude the accumulation of damage. In this review, we focus on the role of hydrogen peroxide, H2O2, as a signaling molecule regulating protein synthesis at different levels, including transcription and various parts of the translation process, e.g., initiation, elongation, termination and ribosome recycling.

Protein synthesis

Hydrogen peroxide


Cysteine thiols


Cecilia Picazo Campos

Universitat de Valencia

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Mikael Molin

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology


2076-3921 (eISSN)

Vol. 10 6 952

Subject Categories

Cell Biology

Biochemistry and Molecular Biology

Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)





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7/1/2021 1