Design and development of a photoswitchable DFG-out kinase inhibitor
Journal article, 2021
We report the synthesis and characterisation of a photoswitchable DFG-out kinase inhibitor. Photocontrol of the target kinase in both enzymatic and living cell assays is demonstrated.
Author
Yongjin Xu
University of Gothenburg
Chunxia Gao
University of Gothenburg
Liliana Haversen
University of Gothenburg
Thomas Lundback
AstraZeneca AB
Joakim Andreasson
Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry
Morten Grotli
University of Gothenburg
Chemical Communications
1359-7345 (ISSN) 1364-548X (eISSN)
Vol. 57 78 10043-10046Subject Categories
Cell and Molecular Biology
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Medicinal Chemistry
Areas of Advance
Health Engineering
DOI
10.1039/d1cc04125h
PubMed
34505602