How nanoparticles can induce dimerization and aggregation of cells in blood or lymph
Journal article, 2021

By analogy with virions, the binding of biologically-inspired nanoparticles with ligands to the cellular membrane containing receptors depends on the multivalent ligand–receptor interaction, membrane bending, and cytoskeleton deformation. The interplay of these factors results in the existence of the potential minimum and activation barrier on the pathway towards full absorption of a NP. Herein, I hypothesize and show theoretically that the interaction of a NP, bound to one cell, with another cell can stabilize the potential minimum and increase the corresponding activation barrier, i.e., NPs can mediate the formation of long-living pairs of cells and aggregates containing a few cells inside blood and lymphatic vessels.

Cells

Lipid membrane

Model

Nanoparticles

Vessels

Aggregation

Author

Vladimir Zhdanov

Russian Academy of Sciences

Chalmers, Physics, Nano and Biophysics

BioSystems

0303-2647 (ISSN)

Vol. 210 104551

Subject Categories

Cell Biology

Cell and Molecular Biology

Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

Areas of Advance

Health Engineering

DOI

10.1016/j.biosystems.2021.104551

PubMed

34597710

More information

Latest update

10/18/2021