Ameliorating microalgal OMEGA production using omics platforms
Review article, 2024

Over the past decade, the focus on omega (ω)-3 fatty acids from microalgae has intensified due to their diverse health benefits. Bioprocess optimization has notably increased ω-3 fatty acid yields, yet understanding of the genetic architecture and metabolic pathways of high-yielding strains remains limited. Leveraging genomics, transcriptomics, proteomics, and metabolomics tools can provide vital system-level insights into native ω-3 fatty acid-producing microalgae, further boosting production. In this review, we explore ‘omics’ studies uncovering alternative pathways for ω-3 fatty acid synthesis and genome-wide regulation in response to cultivation parameters. We also emphasize potential targets to fine-tune in order to enhance yield. Despite progress, an integrated omics platform is essential to overcome current bottlenecks in optimizing the process for ω-3 fatty acid production from microalgae, advancing this crucial field.

metabolomics

genomics

synthetic biology

bioprocess

transcriptomics

Author

Iqra Mariam

Luleå University of Technology

Maurizio Bettiga

Chalmers, Life Sciences, Industrial Biotechnology

Società Benefit

Ulrika Rova

Luleå University of Technology

P. Christakopoulos

Luleå University of Technology

Leonidas Matsakas

Luleå University of Technology

Alok Patel

Luleå University of Technology

Trends in Plant Science

1360-1385 (ISSN)

Vol. 29 7 799-813

Subject Categories

Biochemistry and Molecular Biology

Bioprocess Technology

Microbiology

DOI

10.1016/j.tplants.2024.01.002

PubMed

38350829

More information

Latest update

7/13/2024