Compartment engineering in yeast: a path to increased biochemical production
Review article, 2025
In recent years, there has been growing interest in subcellular compartmentalization of biosynthetic pathways in yeast, with the goal of developing cell factories for more efficient production of value-added chemicals. This review examines recent advances in compartmentalization strategies involving different subcellular organelles in various yeast species for a range of target biochemicals. We also discuss the advantages of these approaches, along with the challenges they present. Finally, we offer new insights into how this innovative strategy can be integrated into the existing yeast metabolic engineering toolbox.
Compartmentalization
Microbial cell factory
Yeast
Biochemical production
Metabolic engineering
Author
Yuyang Wang
Tianjin Univ Sci & Technol
Liyan Cao
Tianjin Univ Sci & Technol
Lanxin Rong
Tianjin Univ Sci & Technol
Chen Ding
Tianjin Univ Sci & Technol
Chang Liu
Tianjin Univ Sci & Technol
Qingqing Ye
Tianjin Univ Sci & Technol
Qingeng Huang
Biol Res Co Ltd
Paitai Biotechnol Changzhou Co Ltd
Cui-ying Zhang
Tianjin Univ Sci & Technol
Ning Xu
Chinese Academy of Sciences
Jiwei Mao
Chalmers, Life Sciences, Systems and Synthetic Biology
Jee Loon Foo
National University of Singapore (NUS)
Natl Ctr Engn Biol
Aiqun Yu
Tianjin Univ Sci & Technol
Chemical Engineering Journal
1385-8947 (ISSN)
Vol. 524 169279Subject Categories (SSIF 2025)
Molecular Biology
Composite Science and Engineering
DOI
10.1016/j.cej.2025.169279