Compartment engineering in yeast: a path to increased biochemical production
Review article, 2025
In recent years, there has been growing interest in subcellular compartmentalization of biosynthetic pathways in yeast, with the goal of developing cell factories for more efficient production of value-added chemicals. This review examines recent advances in compartmentalization strategies involving different subcellular organelles in various yeast species for a range of target biochemicals. We also discuss the advantages of these approaches, along with the challenges they present. Finally, we offer new insights into how this innovative strategy can be integrated into the existing yeast metabolic engineering toolbox.
Yeast
Biochemical production
Microbial cell factory
Compartmentalization
Metabolic engineering
Author
Yuyang Wang
Tianjin University of Technology
Liyan Cao
Tianjin University of Technology
Lanxin Rong
Tianjin University of Technology
Chen Ding
Tianjin University of Technology
Chang Liu
Tianjin University of Technology
Qingqing Ye
Tianjin University of Technology
Qingeng Huang
Paitai Biotechnology (Changzhou) Co.
Qingyuan One Alive Institute of Biological Research Co.
Cui-ying Zhang
Tianjin University of Technology
Ning Xu
Chinese Academy of Sciences
Jiwei Mao
Chalmers, Life Sciences, Systems and Synthetic Biology
Jee Loon Foo
National Centre for Engineering Biology (NCEB)
National University of Singapore (NUS)
Aiqun Yu
Tianjin University of Technology
Chemical Engineering Journal
1385-8947 (ISSN)
Vol. 524 169279Subject Categories (SSIF 2025)
Molecular Biology
Composite Science and Engineering
DOI
10.1016/j.cej.2025.169279