Towards One Health action for addressing antimicrobial resistance in the age of polycrisis
Review article, 2026
Antimicrobial resistance (AMR) represents a major One Health issue, driven by a myriad of potential accelerators that include emerging climate and social challenges. There is little doubt about the need for interventions at critical control points to reduce AMR, but addressing AMR within a single realm of One Health (for example, human, animal or environmental) is not sufficient to reduce it. Building on the past decade of research, this Perspective highlights comprehensive, systemic and integrative strategies that address the effects of anthropogenic activities and the complex relationship between humans and the environment as key targets for intersectoral and global action.
Author
Ishi Keenum
Michigan Technological University
Thomas U. Berendonk
Technische Universität Dresden
Jonas Bonnedahl
Linköping University
Eddie Cytryn
Agr Res Org
Christophe Dagot
University of Limoges
Antti Karkman
University of Helsinki
Despo Fatta-Kassinos
University of Cyprus
April Hayes
University of Exeter
Alexander Kirschner
Medical University of Vienna
Jan-Ulrich Kreft
University of Birmingham
Celia M. Manaia
Catholic University of Portugal
Christophe Merlin
University of Lorraine
Naziza Rahman
McGiIll Univ
Holly Tipper
UK Centre For Ecology & Hydrology (UKCEH)
Máté Vass
Chalmers, Life Sciences, Systems and Synthetic Biology
Arthur Zastepa
Environment and Climate Change Canada
Nature Sustainability
23989629 (eISSN)
Vol. 9 1 24-34Subject Categories (SSIF 2025)
Public Health, Global Health and Social Medicine
DOI
10.1038/s41893-025-01753-z