Pubertal timing predicts previous fractures and BMD in young adult men: the GOOD study.
Journal article, 2006

The importance of pubertal timing for adult BMD in males was studied through association of pubertal timing with young adult bone phenotype. Pubertal timing was found to predict both cortical and trabecular volumetric BMD and previous fractures in young adult men. Thus, late puberty is a risk factor for low BMD and previous fractures in young adult men. INTRODUCTION: Peak bone mass (PBM), achieved during puberty, is a determinant of the risk for osteoporosis and future fractures. The role of variations within the normal range in pubertal timing for fractures during pubertal development and for adult bone mass in men is unknown. MATERIALS AND METHODS: The aim of this study was to investigate the importance of pubertal timing for adult BMD and for fractures before achievement of PBM in men. The population-based Gothenburg Osteoporosis and Obesity Determinants (GOOD) study is a well-characterized cohort of young adult Swedish males 18-20 years of age. Detailed growth charts from birth to 18-20 years of age were retrieved for 642 men participating in the GOOD study. Age at peak height velocity (PHV) was estimated and used as an assessment of pubertal timing. The skeletal phenotype was analyzed at young adult age using DXA and pQCT and previous fractures were assessed by questionnaires. RESULTS: Age at PHV was a negative independent predictor of both adult cortical and trabecular volumetric BMD and of total body and radius areal BMD. Moreover, age at PHV was associated with previous fractures in a logistic regression analysis. The OR for cortical osteopenia was 2.49 (95% CI, 1.91-3.24; p < 0.001) and for previous upper limb fractures was 1.35 (95% CI, 1.04-1.75; p < 0.05) per year increment in age at PHV. CONCLUSIONS: Age at PHV is a negative independent predictor of BMD and a positive predictor of previous fractures in young adult men. Longitudinal studies to determine if pubertal timing also predicts BMD and fractures in elderly men are required.

Absorptiometry

Age of Onset

Fractures

Bone

Adult

Tomography

Male

Bone Density

epidemiology

Humans

Photon

Cohort Studies

X-Ray Computed

Puberty

Author

Jenny Kindblom

University of Gothenburg

Mattias Lorentzon

University of Gothenburg

Ensio Norjavaara

University of Gothenburg

Åsa Hellqvist

University of Gothenburg

Staffan Nilsson

Chalmers, Mathematical Sciences, Mathematical Statistics

University of Gothenburg

Dan Mellström

University of Gothenburg

Claes Ohlsson

University of Gothenburg

Journal of Bone and Mineral Research

0884-0431 (ISSN)

Vol. 21 5 790-5

Subject Categories

MEDICAL AND HEALTH SCIENCES

DOI

10.1359/jbmr.020602

PubMed

16734395

More information

Created

10/7/2017