Increasing peripheral artery intima thickness from childhood to seniority
Journal article, 2007

Background - Using new, very high-resolution ultrasound biomicroscopy, we examined the thickness of artificial layers of silicone and intima thickness (IT) of radial and anterior tibial arteries in healthy subjects and in patients with vascular disease. Methods and Results - Silicone layers of varying thicknesses and mesenteric artery specimens obtained from 18 patients undergoing colectomy were measured by both ultrasound biomicroscopy (55 MHz) and morphometry. There was high correlation (r > 0.9; P < 0.0001) between IT and intima area versus ultrasound biomicroscopy. In 90 healthy subjects (aged between 10 and 90 years), radial and anterior tibial arterial IT and intima-media thickness were measured, as was carotid intima-media thickness in 56 of these subjects. Age was strongly related with both media thickness and IT of both peripheral arteries. Correlations were found between carotid intima-media thickness and both radial and anterior tibial IT/intima-media thickness (r=0.44 to 0.53; P < 0.0001). The IT-to-lumen diameter ratio increased with age and was larger at all ages in the anterior tibial artery (0.067 +/- 0.034) versus the radial artery (0.036 +/- 0.012; P < 0.0001). A thicker radial intimal layer was found in patients with peripheral artery disease. Conclusion - This study is the first to our knowledge in humans to show the feasibility of measuring IT of the radial and anterior tibial arteries using very high-resolution ultrasound. IT progresses with age, and the IT-to-lumen diameter ratio is largest in the arteries of the foot. Assessment of IT by ultrasound biomicroscopy may aid in detecting early peripheral vascular abnormalities.

ultrasound

MEDIA THICKNESS

ULTRASOUND

CARDIOVASCULAR RISK-FACTORS

WALL THICKNESS

intima media

thickness

CAROTID-ARTERY

YOUNG-ADULTS

CORONARY ATHEROSCLEROSIS

atherosclerosis

cardiovascular disease children

Author

Walter Osika

Frida Dangardt

Julia Grönros

University of Gothenburg

Ulf Lundstam

A. Myredal

M. Johansson

R. Volkmann

Tomas Gustavsson

Chalmers, Signals and Systems, Signalbehandling och medicinsk teknik, Imaging and Image Analysis

Li-Ming Gan

University of Gothenburg

Peter Friberg

Chalmers, Signals and Systems

Arteriosclerosis, Thrombosis, and Vascular Biology

1079-5642 (ISSN) 1524-4636 (eISSN)

Vol. 27 3 671-676

Subject Categories

Computer and Information Science

DOI

10.1161/01.ATV.0000256468.95403.6f

PubMed

17194890

More information

Created

10/7/2017