Internal standard in surface-enhanced Raman spectroscopy
Journal article, 2004
A method is presented for the use of SAM layers as internal standards for calibration in surface-enhanced Raman spectroscopy. Three cyano-containing compounds were attached to gold colloids via a metal-sulfur bond and evaluated for spectral stability and normalization capacity. The results show that the analyte, rhodamine 6G, and the internal standard signal enhancement covaried, and it was possible to quantify the analyte with PLS. The fact that the enhancing substrate was chaotic assemblies with large variation in signal enhancement shows the versatility of this method.
PCA
internal standard
SAM
PLS
SERS
multivariate analysis
chemical imaging
surface enhanced Raman spectroscopy
gold nanoparticles
self-assembled monolayer
principal components analysis
Author
Anders Lorén
Chalmers, Department of Chemistry and Bioscience, Analytical and Marine Chemistry
Johan Engelbrektsson
Chalmers, Department of Chemistry and Bioscience, Analytical and Marine Chemistry
Charlotte Eliasson
Chalmers, Department of Chemistry and Bioscience, Analytical and Marine Chemistry
Mats Josefson
Chalmers
AstraZeneca AB
Jonas Abrahamsson
University of Gothenburg
Magnus Johansson
Chalmers, Department of Chemistry and Bioscience, Organic Chemistry
Katarina Abrahamsson
Chalmers, Department of Chemistry and Bioscience, Analytical and Marine Chemistry
Analytical Chemistry
0003-2700 (ISSN) 1520-6882 (eISSN)
Vol. 76 24 7391-7395Subject Categories
Analytical Chemistry
Chemical Sciences
DOI
10.1021/ac0491298