Investigation of critical polymer properties for polymer release and swelling of HPMC matrix tablets
Journal article, 2009
Four different HPMC batches were characterized to investigate properties related to crit. functionality for their use in hydrophilic matrix tablets. In this study, the HPMC batches were chem. characterized and correlated to the behavior of pure HPMC tablets. Parameters such as the mol. wt., viscosity, intrinsic viscosity and radius of gyration were kept in a rather limited range, which resulted in a weak correlation to polymer release and degree of swelling. The hydrophilic/hydrophobic character of the HPMC samples was elucidated by the degree of substitution and by the clouding behavior, where an increased hydrophilicity increased the tablet swelling. This phenomenon was interpreted in a refined model for water transport into HPMC tablets. A five times slower polymer release and a considerably larger degree of swelling were found for one batch of HPMC tablets compared to the others, although the characterized av. polymer parameters were in the same range. However, the conformation plot displayed a fraction with compact aggregates. In conclusion, the existence of aggregates in aq. soln. seems to perturb the functionality of HPMC tablets and it seems important to understand and characterize these aggregates to fully predict the polymer release and swelling of HPMC tablets.
Molecular weight
USES (Uses) (crit. polymer properties for polymer release and swelling of HPMC matrix tablets)
Pharmaceutical tablets
HPMC polymer swelling release hydrophilic matrix tablet
Viscosity (crit. polymer properties for polymer release and swelling of HPMC matrix tablets)
Tensile strength
BIOL (Biological study)
Swelling
Radius of gyration
Cloud point
Dissolution
Polymers Role: PRP (Properties)
Particle size distribution
Hydrophilicity
THU (Therapeutic use)
Author
Anna Viridén
SuMo Biomaterials
Chalmers, Chemical and Biological Engineering, Pharmaceutical Technology
Bengt Wittgren
AstraZeneca AB
Anette Larsson
Chalmers, Chemical and Biological Engineering, Pharmaceutical Technology
SuMo Biomaterials
European Journal of Pharmaceutical Sciences
0928-0987 (ISSN) 1879-0720 (eISSN)
Vol. 36 2-3 297-309Subject Categories
Pharmaceutical Sciences
DOI
10.1016/j.ejps.2008.10.021
PubMed
19038336