Cocatalytic Enzyme System for the Michael Addition Reaction of in-situ-Generated ortho-Quinones
Journal article, 2009
A laccase-lipase cocatalytic system was used to catalyze the domino reaction between catechols and nucleophilic reagents including 1,3-dicarbonyl compounds and aromatic amines in aqueous medium at room temperature. Lipase acted as a catalyst for Michael addition step, and also enhanced the overall yield of the final products.
laccase
Laccase
Lipase
Cascade reaction
Quinones
acid
Michael addition
formation
3 consecutive biotransformations
carbon bond
benzofuran
one-pot synthesis
derivatives
electrochemical oxidation
fully aqueous-medium
cascade reactions
Enzyme catalysis
lipase
Author
S. Witayakran
Georgia Institute of Technology
Art Ragauskas
Chalmers, Chemical and Biological Engineering, Forest Products and Chemical Engineering
European Journal of Organic Chemistry
1434-193X (ISSN) 10990690 (eISSN)
3 358-363Subject Categories
Other Engineering and Technologies not elsewhere specified
DOI
10.1002/ejoc.200800791