Searching for genes influencing a complex disease: the case of coeliac disease.
Journal article, 2008

Recently, a few genes have been reported to be causative in inflammatory diseases. Still, we are waiting for the vast majority to be discovered. New tools for genotyping and statistical analysis have been developed and emphasis has been put on study design. Coeliac disease (CD) is a disorder, where prolamins in dietary wheat gluten and related proteins from rye or barley are not tolerated. It is one of the most common chronic diseases in humans exceeding a population prevalence of 1%. In this article, we will summarise what is currently known about the genetics influencing CD with the emphasis on the non-HLA genetic component. We will discuss some difficulties when searching for susceptibility genes in disorders with complex inheritance patterns.

Evolution

Population

genetics

Humans

epidemiology

Genetic Predisposition to Disease

Celiac Disease

Phenotype

Linkage (Genetics)

Genetics

Author

Åsa Torinsson Naluai

University of Gothenburg

Henry Ascher

University of Gothenburg

Staffan Nilsson

Chalmers, Mathematical Sciences, Mathematical Statistics

University of Gothenburg

Jan Wahlström

University of Gothenburg

European Journal of Human Genetics

1018-4813 (ISSN) 1476-5438 (eISSN)

Vol. 16 5 542-53

Subject Categories

Dermatology and Venereal Diseases

DOI

10.1038/sj.ejhg.5201918

PubMed

17726483

More information

Created

10/7/2017