Adsorption of proteins on a lipid bilayer
Journal article, 2010
In our analysis of protein adsorption on a lipid bilayer, the protein surface is considered to contain one or a few charged spots, and the bilayer contains a significant amount of lipids with oppositely charged head groups. After adsorption, a folded protein is assumed to change its shape slightly due to the electrostatic attraction, so that one of the spots forms a flat contact with the oppositely charged lipid heads of the lipid bilayer. With realistic parameters, this model predicts that the contribution of electrostatic interactions to the protein adsorption energy per charged amino acid-lipid pair is 16-25 kJ/mol. Thus, a few (four or five) pairs is sufficient for irreversible adsorption.
Adsorption energy
qcm-d
binding
solid-surfaces
monte-carlo simulations
Lipids
membranes
marcks-related
afm
Proteins
Electrostatic interactions
atomic-force microscopy
Poisson-Boltzmann equation
protein
charged macromolecules
Author
Vladimir Zhdanov
Chalmers, Applied Physics, Chemical Physics
Bengt Herbert Kasemo
Chalmers, Applied Physics, Chemical Physics
European Biophysics Journal
0175-7571 (ISSN) 1432-1017 (eISSN)
Vol. 39 11 1477-1482Subject Categories
Physical Sciences
DOI
10.1007/s00249-010-0604-0