Sustained release of nucleic acids from polymeric nanoparticles using microemulsion precipitation in supercritical carbon dioxide
Journal article, 2010

A general approach for producing biodegradable nanoparticles for sustained nucleic acid release is presented. The nanoparticles are produced by precipitating a water-in-oil microemulsion in supercritical CO2. The microemulsion consists of a transfer RNA aqueous solution (water phase), dichloromethane containing poly(L-lactic acid)-poly(ethylene glycol) (oil phase), the surfactant n-octyl beta-D-glucopyranoside, and the cosurfactant n-butanol.

rna

emulsions

interference

microspheres

in-vivo

mechanism

sirna

delivery

Author

J. Ge

Stanford University

G. B. Jacobson

Stanford University

Tatsiana Lobovkina

Stanford University

Krister Holmberg

Chalmers, Chemical and Biological Engineering, Applied Surface Chemistry

R. N. Zare

Stanford University

Chemical Communications

1359-7345 (ISSN)

Vol. 46 47 9034-9036

Subject Categories

Chemical Sciences

DOI

10.1039/c0cc04258g

More information

Latest update

3/6/2018 1