Fluorescence Enhancement of Single DNA Molecules Confined in Si/SiO2 Nanochannels

Journal article, 2010

We demonstrate that the detected emission intensity from YOYO- labeled DNA molecules confined in 180 nm deep Si/SiO2 nano- funnels changes significantly and not monotonically with the width of the funnel. This effect may be of importance for quantitative fluorescence microscopy and for experiments with a tight photon budget.