Impaired thymic export and apoptosis contribute to regulatory T-cell defects in patients with chronic heart failure.
Journal article, 2011

Animal studies suggest that regulatory T (T(reg)) cells play a beneficial role in ventricular remodeling and our previous data have demonstrated defects of T(reg) cells in patients with chronic heart failure (CHF). However, the mechanisms behind T(reg-)cell defects remained unknown. We here sought to elucidate the mechanism of T(reg-)cell defects in CHF patients.

immune system

heart

Author

Ting-Ting Tang

Zheng-Feng Zhu

Wen-Cai Zhang

Xin Tu

Hong Xiao

Xin-Ling Du

Jia-Hong Xia

Nian-Guo Dong

Wei Su

Ni Xia

Xing-Xing Yan

Shao-Fang Nie

Juan Liu

Su-Feng Zhou

Rui Yao

Jiang-Jiao Xie

Harish Jevallee

Xiang Wang

Meng-Yang Liao

Guo-Ping Shi

Michael Fu

Yu-Hua Liao

Xiang Cheng

PLoS ONE

1932-6203 (ISSN)

Vol. 6 9 e24272-

Subject Categories

Dermatology and Venereal Diseases

Physiology

Microbiology in the medical area

DOI

10.1371/journal.pone.0024272

PubMed

21935395

More information

Created

10/10/2017