Applications of the Nicholas Reaction in the Synthesis of Natural Products
Journal article, 2012

The Nicholas reaction involves the treatment of a cobalt carbonyl-stabilized propargylic cation with a variety of nucleophiles to form a new carbon-carbon or carbon-heteroatom bond. Several features of this reaction make it especially well suited for applications in natural product synthesis, in particular when cyclic and polycyclic target molecules are involved. This review summarizes the results in this area from the last ten years, including approaches towards terpenes, alkaloids and marine natural products.

terpene

organic-synthesis

propargylic substitution

Nicholas reaction

synthesis

marine polyether

formal synthesis

natural product

cobalt alkyne complex

enantioselective syntheses

stereoselective-synthesis

synthesis

Alkaloid

ciguatoxin 1b

convergent

jklm-ring fragment

8-membered cyclic ethers

acetylene cobalt complex

Author

Nina Kann

Chalmers, Chemical and Biological Engineering, Organic Chemistry

Other publications Research

Current Organic Chemistry

1385-2728 (ISSN)

Vol. 16 3 322-334

Subject Categories

Organic Chemistry

More information

Created

10/7/2017

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